APOE4 drives widespread changes to the hepatic proteome and alters metabolic function

iScience 2026 Open access

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Authors: Colton R Lysaker, Chelsea N. Johnson, Vivien Csikós, Edziu Franczak, Ashley L. Tetlow, Maggie N. Benson, John P. Thyfault, Paige C. Geiger, Jill K. Morris, Heather M. Wilkins
DOI: 10.1016/j.isci.2026.115035
Cited by: 4
References: 66

Abstract

genetic variation causes mitochondrial dysfunction and rewires hepatic metabolism.

Fields of Study & Subjects

Liver Disease Diagnosis and Treatment Protein Kinase Regulation and GTPase Signaling Protein Tyrosine Phosphatases

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
115035–115035
Publication date
17 February 2026
Language
EN