Modeling embryonic heart vascular plexus development and sympathetic innervation on a human heart organoid

iScience 2026 Open access

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Authors: Mariana A. Branco, Jacek Marzec, Mafalda Marques Nunes, Marta Bica, Ana Luísa Rayagra, Miguel F. Tenreiro, Joaquim M.S. Cabral, Maria Margarida Diogo
DOI: 10.1016/j.isci.2026.115071
Cited by: 2
References: 52

Abstract

processes. Assembly of these vascularized EMOs with human iPSC-derived sympathetic neuron spheroids yields innervated EMOs exhibiting integrated neurovascular organization and functional responses to nicotine stimulation (iV-EMOs). This modular, developmentally guided organoid system features coordinated human cardiac, vascular, and neural development, providing a physiologically relevant platform for studying heart morphogenesis, neurovascular interactions, and regenerative therapeutic strategies.

Fields of Study & Subjects

Congenital heart defects research Cardiac electrophysiology and arrhythmias Neuroscience of respiration and sleep

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
115071–115071
Publication date
25 February 2026
Language
EN