pH-responsive CaCO3 nanoplatform amplifies SDT via calcium overload-ROS loop for deep tumor therapy

iScience 2026 Open access

Read full text
Authors: Miao Chen, Yan Wang, Yiran Niu, Xiaomin Chen, Hang Su, Liang Xia, Chunbao Liu, Junfen Zhou, Zhen Wang, Bao Qiang Li, Diyu Lu
DOI: 10.1016/j.isci.2026.115082
Cited by: 2
References: 39

Abstract

, it achieved 90.9% tumor inhibition and 80% 60-day survival rate, alleviated tumor hypoxia, and inhibited tumor proliferation and angiogenesis. This "ion-interference SDT" paradigm overcomes the limitations of SDT through self-amplified ROS cycle and provides an effective strategy for treating deep-seated solid tumor with significant clinical translation potential.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Calcium Carbonate Crystallization and Inhibition Marine Sponges and Natural Products

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
115082–115082
Publication date
24 February 2026
Language
EN