Platelet DKK1 promotes tolerogenic dendritic cells and non-healing responses in cutaneous leishmaniasis

iScience 2026 Open access

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Authors: Olivia C. Ihedioha, Anutr Sivakoses, Haley Q. Marcarian, Malini Sajeev, Diane McMahon‐Pratt, Alfred L.M. Bothwell
DOI: 10.1016/j.isci.2026.115090
Cited by: 1
References: 76

Abstract

infection. The current study extends the prior study and demonstrates that DKK1 directly regulates both Th2 and IL-10-Th1 responses by inducing regulatory, tolerogenic DC-10 cells.

Fields of Study & Subjects

Research on Leishmaniasis Studies Phagocytosis and Immune Regulation Mast cells and histamine

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115090–115090
Publication date
26 February 2026
Language
EN