Crosstalk between circulating DPP3 and immune cells in the context of cardio-systemic stress

iScience 2026 Open access

Read full text
Authors: Noma Assad, Hugo Nordin, Alexis nguyen, Claire Oddos, Gwendolyn Marguerit, Lalou delgado, Isabelle Schiltz, Adrien Picod, Maxime Zalc, Antoine beurton, Marion tanguy, Pierre-emmanuel rautou
+10 more Malha Sadoune, Evelyne Polidano, Jean‐Marie Launay, Karine santos, Nicolas Vodovar, Alexandre Ouattara, Damien logeart, Amélie Calmont, Alexandre mebazaa, Fériel Azibani
DOI: 10.1016/j.isci.2026.115114
Cited by: 2
References: 84

Abstract

mice, cDPP3 increase was comparable to stressed WT mice. DPP3 injection in WT mice induced cardiac neutrophil infiltration. Extracellular vesicles from plasma and bone marrow carried only a minimal fraction of DPP3, indicating mainly soluble release. These results reveal bone marrow-derived cells as a main driver of cDPP3 release under stress and provide a foundation to optimize its use as a biomarker and therapeutic target.

Fields of Study & Subjects

Peptidase Inhibition and Analysis Diabetes and associated disorders Neutrophil Myeloperoxidase and Oxidative Mechanisms

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
115114–115114
Publication date
20 February 2026
Language
EN