Cross-species scRNA-seq finds ideal mouse models for aortic dissection mechanisms

Genmao Cao; Shouji Qiu; Chengkai Hu; Yuanqing Kan; Zheyun Li; Shiyi Li; Qiyuan Feng; Weiguo Fu; Lixin Wang

doi:10.1016/j.isci.2026.115147

Cross-species scRNA-seq finds ideal mouse models for aortic dissection mechanisms

iScience 2026 Open access

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Authors: Genmao Cao, Shouji Qiu, Chengkai Hu, Yuanqing Kan, Zheyun Li, Shiyi Li, Qiyuan Feng, Weiguo Fu, Lixin Wang

DOI: 10.1016/j.isci.2026.115147

Cited by: 1

References: 37

Abstract

model mimicked pathogenic vascular smooth muscle cell phenotypes, particularly lipid-associated and oxidative stress states. Endothelial cell dysfunction was a conserved feature across all models. Our study provides a single-cell-based comparative framework highlighting model-specific transcriptional similarities to human aortic dissection.

Fields of Study & Subjects

Congenital heart defects research Single-cell and spatial transcriptomics Aortic Disease and Treatment Approaches

Publication details

Journal / source: iScience
Publisher: Elsevier BV
Volume: 29
Issue: 3
Pages: 115147–115147
Publication date: 25 February 2026
Language: EN

References 37