Adipose extracellular vesicles carrying miR-210-3p drive macrophage inflammation and nicotine-induced atherosclerosis

iScience 2026 Open access

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Authors: Yanchao Li, Mengyue Yang, Hongyu Li, Yiyi Lei, Meng Zhang, Ziyu Yang, Xingtao Huang, Yufei Sun, Qi Liu, Xuedong Wang, Jingbo Hou
DOI: 10.1016/j.isci.2026.115151
Cited by: 1
References: 44

Abstract

. Mechanistically, miR-210-3p directly targets Krüppel-like factor 7 (KLF7), amplifying macrophage inflammatory responses and promoting plaque progression. Collectively, these findings uncover a previously unrecognized role of adipose-derived EVs in smoking-related vascular injury and highlight EV-derived miR-210-3p as a promising therapeutic target in nicotine-associated atherosclerosis.

Fields of Study & Subjects

Extracellular vesicles in disease MicroRNA in disease regulation Immune cells in cancer

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115151–115151
Publication date
26 February 2026
Language
EN