Peripheral amylin modulation rebalances brain glycolysis and Tau-Ser214 phosphorylation via cAMP-PKA signaling

iScience 2026 Open access

Read full text
Authors: Ravichandra Shivalingappa Davargaon, Nirmal Verma, Deepak Kotiya, Noah Leibold, Gopal V. Velmurugan, Han Coburn, Kuey C. Chen, Daniel Ruíz, Victor G. Corces, Huazhen Liu, Pradeep Kachroo, Pankaj Kumar Singh
+3 more Matthew S. Gentry, Sanda Despa, Florin Despa
DOI: 10.1016/j.isci.2026.115157
Cited by: 2
References: 64

Abstract

. Together, these results define prediabetic hyperamylinemia as an upstream, modifiable driver of PKA-mediated tau pathology linking metabolic dysfunction to AD.

Fields of Study & Subjects

Protein Kinase Regulation and GTPase Signaling Neurogenesis and neuroplasticity mechanisms Alzheimer's disease research and treatments

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
3
Pages
115157–115157
Publication date
26 February 2026
Language
EN