Stage-resolved gene drivers of pancreatic ductal adenocarcinoma progression and therapeutic vulnerabilities

iScience 2026 Open access

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Authors: Eduardo Chuluyan, Brice Chanez, A. Meilerman, Carla Remolins, Andrea Paes de Lima, Kevin Matamoros, Claudio Incardona, Diego Guerrieri, Gustavo Kohan, Florencia Gottardo, Martín de Ledesma, Juan Garona
+16 more Davio Carlos, Agustín Yaneff, Ana Sahores, Daniel Grasso, María Noé Garcia, Daniela Papademetrio, María Eugenia Pasqualini, Luis Sarotto, Felix Gabriel Lezcano, Jonathan Garnier, Analia Pasqua, Oscar Mazza, Pascal Hammel, Nicolas Fraunhoffer, Nelson Dusetti, Juan Iovanna
DOI: 10.1016/j.isci.2026.115164
Cited by: 1
References: 68

Abstract

T cells, dendritic cells, and M1 macrophages. Compact gene signatures stratified stage and survival and generalized to TCGA and ICGC cohorts. Functional assays confirmed greater invasiveness, altered redox balance, and mitochondrial dependence in advanced disease, suggesting stage-associated metabolic vulnerabilities.

Fields of Study & Subjects

Pancreatic and Hepatic Oncology Research Pancreatic function and diabetes Pancreatitis Pathology and Treatment

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115164–115164
Publication date
27 February 2026
Language
EN