An oncolytic vaccinia virus encoding CD47 nanobody potentiates antitumor immunity in multiple myeloma

iScience 2026 Open access

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Authors: Lingli Pan, Xiaomeng Zhu, Jiaqing Zhang, Qingyao Zhong, Hui Wu, Weidong Sun, Yongming Xia, Shibing Wang, Xiangmin Tong
DOI: 10.1016/j.isci.2026.115174
Cited by: 1
References: 48

Abstract

T cell infiltration and function. Transcriptomics revealed enriched pro-inflammatory and phagocytic pathways with downregulated autophagy genes. OVV-αCD47nb synergized with bortezomib to overcome resistance and improve tumor control over monotherapies. This multifunctional viro-immunotherapy strategy, which integrates oncolysis, immune reprogramming, and chemosensitization, offers a promising therapeutic approach for CD47-expressing malignancies.

Fields of Study & Subjects

Immunotherapy and Immune Responses Virus-based gene therapy research Phagocytosis and Immune Regulation

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115174–115174
Publication date
28 February 2026
Language
EN