Multidimensional cfRNA response modeling identifies a 5-gene pair signature for high-robust pulmonary tuberculosis diagnosis

iScience 2026 Open access

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Authors: Changchun Wu, Huiyuan Qiao, Xianrun Pan, Hongyan Lin, Xueqin Xie, Mengze Du, Hao Lin, Jian Hua Huang
DOI: 10.1016/j.isci.2026.115178
Cited by: 1
References: 49

Abstract

= 0.65) and radiological severity. Kappa analysis confirmed substantial diagnostic agreement (kappa = 0.42-0.56) between this signature and chest X-ray systems, with the signature providing high discriminative power in cases with ambiguous radiological findings. This cfRNA-based 5-gene pair signature establishes a robust diagnostic paradigm, offering efficient PTB detection in resource-limited settings and a foundation for future point-of-care diagnostics.

Fields of Study & Subjects

Tuberculosis Research and Epidemiology Diagnosis and treatment of tuberculosis RNA and protein synthesis mechanisms

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115178–115178
Publication date
28 February 2026
Language
EN