Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer

iScience 2026 Open access

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Authors: Eoghan J. Mulholland-Illingworth, Joshua W. Moore, Muyang Lin, Raheleh Amirkhah, Lucile Grzesiak, A. Ligęza, Joshua A. Bull, Joseph Boen, Gabriel N. Valbuena, Michael A. Gillespie, Tamsin R.M. Lannagan, Kathryn Gilroy
+8 more Megan L. Mills, Shania M. Corry, Rachel A. Ridgway, Hayley L. Belnoue-Davis, Philip D. Dunne, Owen J. Sansom, Helen M. Byrne, Simon J. Leedham
DOI: 10.1016/j.isci.2026.115193
Cited by: 2
References: 42

Abstract

, reconfiguring local immune neighborhoods and indirectly altering epithelial stem cell states. Finally, we demonstrate that multiscale spatial analysis provides a quantitative readout of stromal-immune-epithelial remodeling following therapy. These findings establish a simplified, translationally relevant CAF framework and highlight spatially resolved stromal dynamics as measurable indicators of therapeutic response in CRC.

Fields of Study & Subjects

Cancer Cells and Metastasis Cancer Research and Treatments Colorectal Cancer Treatments and Studies

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115193–115193
Publication date
28 February 2026
Language
EN