KIAA1429 promotes clear cell renal cell carcinoma progression by regulating MYC mRNA stability

iScience 2026 Open access

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Authors: Xu Zhu, Cheng Shen, Yong Zhang, Xinfeng Chen, Wei Zhang, Bing Zheng, Zhan Chen
DOI: 10.1016/j.isci.2026.115198
Cited by: 1
References: 42

Abstract

models demonstrate that genetic depletion of KIAA1429 markedly inhibits tumor growth, as well as cancer cell proliferation, migration, and invasion. Mechanistically, KIAA1429 directly binds to the 3' untranslated region (3' UTR) of MYC mRNA and catalyzes site-specific m6A methylation, thereby enhancing transcript stability and augmenting MYC protein expression. Collectively, these findings identify KIAA1429 as a critical m6A-dependent post-transcriptional regulator of MYC and nominate the KIAA1429-MYC regulatory axis as a promising therapeutic target in ccRCC.

Fields of Study & Subjects

Ferroptosis and cancer prognosis RNA Research and Splicing PI3K/AKT/mTOR signaling in cancer

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115198–115198
Publication date
3 March 2026
Language
EN