GAL and F2R as immune diagnostic biomarkers for fetal growth restriction

iScience 2026 Open access

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Authors: Shiying Chen, Yumin Ke, Zhimei Zhou, Yajing Xie, Weihong Chen, Li Huang, Liying Sheng, Yueli Wang, Binbin Chen, Congmei Yang, Zhuna Wu
DOI: 10.1016/j.isci.2026.115228
Cited by: 0
References: 35

Abstract

Fetal growth restriction (FGR) is associated with adverse perinatal outcomes, but reliable diagnostic biomarkers are lacking. Through bioinformatics analysis of public datasets and clinical validation, we identified GAL and F2R as potential immune-related biomarkers associated with FGR. Both genes were consistently upregulated in FGR tissues and correlated with altered immune cell infiltration. These findings suggest that GAL and F2R may serve as diagnostic markers and potential therapeutic targets for FGR, facilitating early intervention and improved neonatal outcomes.

Fields of Study & Subjects

Pregnancy and preeclampsia studies Reproductive System and Pregnancy Birth Development and Health

Publication details

Journal / source
iScience
Volume
29
Issue
4
Pages
115228–115228
Publication date
4 March 2026
Language
EN