An assay toolkit for anti-tuberculosis drugs in the hollow fiber system

iScience 2026 Open access

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Authors: Fernando Sanz-García, Dominique Ndjogou, Diana A. Aguilar-Ayala, Maxime Eveque, Ana Benítez, Sergio Aznar, Nuria Isach-Traver, Alfonso Mendoza-Losana, Nicolas Willand, Ainhoa Lucía, Santiago Ramón-García
DOI: 10.1016/j.isci.2026.115292
Cited by: 2
References: 69

Abstract

models to inform phase II/III clinical trials. Yet, its implementation is challenging due to lack of consolidated technical guidelines, such as the compatibility of drugs with the most commonly used types of HFS-TB cartridges. Herein, we uncovered the compatibility of 10 anti-TB drugs alone: bedaquiline, clarithromycin, delamanid, ethambutol, isoniazid, linezolid, moxifloxacin, pretomanid, rifampicin, and rifapentine; and of a combination, bedaquiline-pretomanid-linezolid. The most hydrophilic compounds were within the compatibility range with all fibers; whereas the lipophilic ones required adjustments to be used in the system. Also, polysulfone and cellulose fibers were the most suitable for the tested drugs. Our data strengthen the importance of these preliminary studies and provide a useful toolkit toward wider HFS-TB implementation.

Fields of Study & Subjects

Spectroscopy Techniques in Biomedical and Chemical Research Tuberculosis Research and Epidemiology Advancements in Transdermal Drug Delivery

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115292–115292
Publication date
10 March 2026
Language
EN