Stimulation to secrete insulin induces pancreatic β-cell dysfunction through Tfe3 activation

iScience 2026 Open access

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Authors: Yuki Aida, Nozomu Kadota, Mimi Takahashi, Yuichi Koshiishi, Koji Kasahara, Kohsuke Kataoka
DOI: 10.1016/j.isci.2026.115312
Cited by: 2
References: 54

Abstract

and other GSIS-related genes and suppresses the enhancer activity. Thus, stimulation to secrete insulin alters transcriptional program in β-cells toward dysfunction through Tfe3 activation.

Fields of Study & Subjects

Pancreatic function and diabetes Erythrocyte Function and Pathophysiology Calcium signaling and nucleotide metabolism

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115312–115312
Publication date
11 March 2026
Language
EN