Transcriptional noise sets fundamental limits to decoding circadian clock phase from single-cell RNA snapshots

iScience 2026 Open access

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Authors: Anjoom Nikhat, Taniya Mandal, Nivedha Veerasubramanian, Shaon Chakrabarti
DOI: 10.1016/j.isci.2026.115394
Cited by: 3
References: 53

Abstract

70 cells enabled robust phase estimation. In desynchronized fibroblasts, spatially heterogeneous phases indicating local inter-cellular coupling were revealed only upon averaging, not at single-cell resolution. Coarse graining is, therefore, essential for circadian phase inference from RNA measurements alone.

Fields of Study & Subjects

Single-cell and spatial transcriptomics Circadian rhythm and melatonin Environmental Monitoring and Data Management

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115394–115394
Publication date
19 March 2026
Language
EN