Mechanical activation of PIEZO1 drives AP-1–dependent PTGS2/PGE2 signaling and corneal inflammation

iScience 2026 Open access

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Authors: Zongzheng Zou, Xiuqing Qian, Jifeng Ren, Yuqing Wang, Yuqi Liu, Aojun Luo, Mengyuan Guo, Hui Tong, Ruiran Li, Shanshan Li, Haixia Zhang
DOI: 10.1016/j.isci.2026.115396
Cited by: 2
References: 47

Abstract

-AP-1-PTGS2/PGE2 axis as a core mechanotransduction pathway driving corneal inflammation. Given the widespread expression of PIEZO1, our results provide mechanistic insight into how abnormal mechanical forces trigger inflammatory responses, highlighting a potential framework for understanding mechano-inflammation across tissues.

Fields of Study & Subjects

Erythrocyte Function and Pathophysiology Phagocytosis and Immune Regulation Sphingolipid Metabolism and Signaling

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
5
Pages
115396–115396
Publication date
1 April 2026
Language
EN