Live and heat-treated Lactiplantibacillus plantarum induce distinct metabolic and immune responses in intestinal epithelial cells

iScience 2026 Open access

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Authors: Kaho Matsumoto, Yuta Takada, Yoshiya Imamura, Hina Yoshida, Kazuhiro Sonomura, Mikako Takahashi, Nobuko Moritoki, Tomoko Shindo, Junya Yamamoto, Leonardo Albarracín, Wakako IKEDA-OHTSUBO, Masatoshi Hori
+6 more Julio Villena, Fu Namai, Yuji Tsujikawa, Toyoyuki Hashimoto, Keita Nishiyama, Haruki Kitazawa
DOI: 10.1016/j.isci.2026.115516
Cited by: 1
References: 63

Abstract

-dependent manner, likely in response to alterations in bacterial surface components. Our findings demonstrate that bacterial viability influences host epithelial metabolic and immune responses, providing a mechanistic basis for the rational selection of probiotic or postbiotic strategies.

Fields of Study & Subjects

Probiotics and Fermented Foods Gut microbiota and health Polysaccharides and Plant Cell Walls

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
5
Pages
115516–115516
Publication date
1 April 2026
Language
EN