pH-responsive Folate-PEG modified ZIF-8 Nanoparticles deliver fisetin to Aquaporin-3 for cervical cancer therapy

iScience 2026 Open access

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Authors: Hanlin Yang, Weiwei Li, Hailong Zhang, Yameng Liu, Miaomiao Cui, Yurong Zhu, Li Hou, Shaoju Min, Jie Ren, Yujie Tan
DOI: 10.1016/j.isci.2026.115521
Cited by: 1
References: 52

Abstract

models demonstrate that this system effectively suppresses cancer cell proliferation, migration, and tumor growth with excellent biocompatibility. Mechanistically, transcriptomic and lipidomic analyses reveal that PEG-FA@ZIF-8@FIS exerts its anticancer effects by downregulating aquaporin-3 (AQP3) expression, which subsequently disrupts tumor lipid metabolism. By linking AQP3 inhibition to metabolic impairment via a targeted delivery platform, this work establishes a highly biocompatible and effective translational strategy for cervical cancer intervention.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Cancer Hypoxia and Metabolism Nanoparticle-Based Drug Delivery

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
4
Pages
115521–115521
Publication date
30 March 2026
Language
EN