Use of hollow fiber systems to model treatment of infections: A practical guide

iScience 2026 Open access

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Authors: Jelmer Raaijmakers, Fernando Sanz-García, Zahra Sadouki, Diana A. Aguilar-Ayala, Andrew Mead, John Readman, Timothy D. McHugh, L. Pelligand, Joseph F. Standing, Santiago Ramón-García, Jakko van Ingen, Frank Kloprogge
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DOI: 10.1016/j.isci.2026.115535
Cited by: 3
References: 31

Abstract

This EPASG-endorsed consensus report provides practical and standardized guidance for the use of hollow fiber systems (HFSs) in modeling antimicrobial treatment of bacterial infections. An HFS allows the simulation of dynamic pharmacokinetic (PK) profiles and bacterial responses over extended time periods, making it highly suited for PK/pharmacodynamic (PD) studies. This document serves as a foundational reference for researchers using HFS to evaluate antimicrobial efficacy, optimize dosing regimens, and support translational research in infectious diseases.

Fields of Study & Subjects

Orthopedic Infections and Treatments Antimicrobial agents and applications Infectious Aortic and Vascular Conditions

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
6
Pages
115535–115535
Publication date
31 March 2026
Language
EN