LCPBert: ProtBERT-based early-stage lung cancer prediction from T cell receptor beta sequences

iScience 2026 Open access

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Authors: Xin Yang, Yu Zhou, Zixuan Zhang, Huaichao Luo, Jian Hua Huang
DOI: 10.1016/j.isci.2026.115581
Cited by: 1
References: 43

Abstract

< 0.084). At an LCRI cutoff of 0.1465, LCPBert achieved 75% sensitivity and 70% specificity in discriminating lung cancer patients from healthy individuals. In a longitudinal cohort, LCRI elevation (Δ > 0.15) exceeding 0.30 after SBRT predicted distant metastasis (DM) in 75% of patients who developed DM. In addition, LCRI predicted lung cancer independently of age, sex, and TCR diversity (D50). LCPBert provides an accurate and non-invasive approach for early-stage lung cancer detection.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers vaccines and immunoinformatics approaches T-cell and B-cell Immunology

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
5
Pages
115581–115581
Publication date
2 April 2026
Language
EN