Enterohemorrhagic Escherichia coli senses colonic oxygen availability to modulate its virulence and colonization

iScience 2026 Open access

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Authors: Fang Fang, Yunhe Li, Ying Zhong, Xuefang Xu, Tanliang Ouyang, Jinping Han, Liangding Dou, Yunxin Xue, Dai Wang
DOI: 10.1016/j.isci.2026.115632
Cited by: 1
References: 33

Abstract

, reflecting evolutionary adaptation. Additionally, ArcA suppresses Shiga toxin production. Our work reveals the ArcAB two-component system as a pivotal oxygen-sensing pathway that directly orchestrates locus of enterocyte effacement (LEE) gene expression and positions it as a promising target for antivirulence or metabolic interference strategies.

Fields of Study & Subjects

Escherichia coli research studies Bacterial Genetics and Biotechnology Vibrio bacteria research studies

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
5
Pages
115632–115632
Publication date
7 April 2026
Language
EN