Hmgcs1 regulates cholesterol synthesis and promotes nerve fiber repair after spinal cord injury

iScience 2026 Open access

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Authors: Yingfan Pei, Guoying Feng, Yaorui Hu, Jiaran Tang, Naili Zhang, Shuai Zhou, Chunlei Zhang, Fei Huang, Luping Zhang
DOI: 10.1016/j.isci.2026.115692
Cited by: 1
References: 34

Abstract

co-culture system. Finally, RNA sequencing (RNA-seq) and quantitative reverse-transcription PCR (qRT-PCR) were integrated to elucidate Hmgcs1-mediated signaling pathways by validating downstream target gene expression. The results demonstrated that Hmgcs1 overexpression enhanced cholesterol synthesis in astrocytes post-injury, effectively promoted neuronal myelin repair, axonal regeneration, and improved motor functional recovery in rats. Notably, neuropilin-1 (Nrp1) expression exhibited Hmgcs1-dependent regulation.

Fields of Study & Subjects

Nerve injury and regeneration Spinal Cord Injury Research Inflammasome and immune disorders

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
5
Pages
115692–115692
Publication date
10 April 2026
Language
EN