Nicotinamide mononucleotide stimulates the activity of bursting slow-oscillation neurons in the supramammillary nucleus and enhances REM sleep

iScience 2026 Open access

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Authors: Youssouf Cissé, Cynthia S. Brace, Virginia Hsu, Carla M. Yuede, Nicholas Rensing, Michael Wong, Shin‐ichiro Imai
DOI: 10.1016/j.isci.2026.115741
Cited by: 1
References: 42

Abstract

-deficient mice show defects in NMN response, decreased percent theta power during REM sleep, and impaired novel object recognition. Optogenetic stimulation of the SuM GABAergic neurons projecting to the cortex triggers cortical SO and theta rhythm, whereas chemogenetic inhibition of those neurons predominantly decreases REM sleep. These findings suggest that NMN stimulates SuM bursting SO neurons and promotes REM sleep during aging.

Fields of Study & Subjects

Sleep and Wakefulness Research Calcium signaling and nucleotide metabolism Neuroscience and Neuropharmacology Research

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
5
Pages
115741–115741
Publication date
15 April 2026
Language
EN