Propranolol alleviates cerebral infarction through the β2-AR-mediated ERK/NLRP3 pathway

iScience 2026 Open access

Read full text
Authors: Meng‐Meng Zhu, Tianxiao Li, Xue-Ting Liu, Xiu Chen, Na Zhao, Fan Geng, Zhi-Jun Zhang, Lei Zuo, Qing-Guo Ren
DOI: 10.1016/j.isci.2026.115779
Cited by: 1
References: 66

Abstract

-ERK1/2 and NLRP3 in BV2 cells. Furthermore, U0126 treatment also lowered NLRP3 and IL-1β levels. These results demonstrated the important role of β2-AR signaling in regulating the inflammatory response in ischemic stroke.

Fields of Study & Subjects

Inflammasome and immune disorders Neuroinflammation and Neurodegeneration Mechanisms Fatty Acid Research and Health

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
5
Pages
115779–115779
Publication date
17 April 2026
Language
EN