USP18 promotes clear cell renal cell carcinoma progression by regulating the ubiquitination and stability of YBX3

iScience 2026 Open access

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Authors: Chen Wang, Yihui He, Zhijie You, Siqi Chen, Xin Chen, Xin Chen
DOI: 10.1016/j.isci.2026.115808
Cited by: 3
References: 37

Abstract

, USP18 deficiency inhibits xenograft tumor growth by decreasing YBX3 expression and blocking the PI3K/AKT pathway. Our findings underscore the therapeutic potential of targeting the USP18-YBX3 axis in ccRCC treatment.

Fields of Study & Subjects

Ubiquitin and proteasome pathways 14-3-3 protein interactions Hippo pathway signaling and YAP/TAZ

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
5
Pages
115808–115808
Publication date
17 April 2026
Language
EN