The CD49b (ITGA2) collagen receptor excludes CD8+ T cell infiltration in pancreatic ductal adenocarcinoma

iScience 2026 Open access

Read full text
Authors: Ibrahim Ragab Eissa, Sonia Cohen, Genevieve M. Boland, Tatyana Sharova, Kenneth K. Tanabe
DOI: 10.1016/j.isci.2026.116500
Cited by: 1
References: 55

Abstract

T cell infiltration. These findings identify CD49b as a regulator of collagen-mediated immune exclusion in PDAC and support its evaluation as a therapeutic target.

Fields of Study & Subjects

T-cell and B-cell Immunology Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
7
Pages
116500–116500
Publication date
23 June 2026
Language
EN