Dose-response framework for DSS-induced colitis in mice

iScience 2026 Open access

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Authors: Siyan Che, Jinglong Peng, Xia Xu, Yue Wang, Mujie Huang, Lin Zhao, Bin Feng, Pan Huang, Li J, Miaomiao Wu, Yulong Yin
DOI: 10.1016/j.isci.2026.116892
Cited by: 1
References: 35

Abstract

T cell accumulation. Higher doses (2.5%-3.0%) caused sustained inflammation, pronounced mucosal damage, macrophage and granulocyte infiltration, and elevated pro-inflammatory cytokines. Transcriptomic analysis revealed shared activation of TNF, NF-κB, IL-17, and NOD-like receptor signaling, with greater amplitude at higher DSS concentrations. This framework supports rational DSS dose selection according to disease severity and experimental objectives.

Fields of Study & Subjects

Inflammatory Bowel Disease Neutrophil Myeloperoxidase and Oxidative Mechanisms Microscopic Colitis

Publication details

Journal / source
iScience
Publisher
Elsevier BV
Volume
29
Issue
8
Pages
116892–116892
Publication date
22 July 2026
Language
EN