Cytokine specificity in macrophages: JAK-STAT and beyond

Trends in Immunology 2026 Open access

Read full text
Authors: Josje M.A. Huisman, Alexandra Drakaki, Thomas Decker, Marten A. Hoeksema
DOI: 10.1016/j.it.2026.01.002
Cited by: 2
References: 15

Abstract

Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.

Fields of Study & Subjects

Cytokine Signaling Pathways and Interactions Immune cells in cancer Phagocytosis and Immune Regulation

Publication details

Journal / source
Trends in Immunology
Publisher
Elsevier BV
Volume
47
Issue
4
Pages
255–258
Publication date
27 February 2026
Language
EN