Flt3L from interfollicular stroma maintains resident dendritic cells

Trends in Immunology 2026 Open access

Read full text
Authors: Arpa Aintablian, Ayse Nihan Kilinc, Angela Riedel
DOI: 10.1016/j.it.2026.01.010
Cited by: 0
References: 10

Abstract

Dendritic cell (DC) maintenance and positioning are essential for their function in lymph nodes. Wu et al. identify gremlin1 (Grem1) + fibroblastic reticular cells as critical source of niche-specific Fms-like tyrosine kinase 3 ligand (Flt3L) for conventional DC maintenance in health and disease, highlighting stromal cells as key regulators of immunity.

Fields of Study & Subjects

Immunotherapy and Immune Responses T-cell and B-cell Immunology Immune Response and Inflammation

Publication details

Journal / source
Trends in Immunology
Volume
47
Issue
2
Pages
93–95
Publication date
1 February 2026
Language
EN