Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity
Abstract
During pregnancy, complex interactions of maternal immune cells and fetal extravillous trophoblasts (EVTs) orchestrate placentation, immune tolerance, and immune defense. This forum article highlights important discoveries and outstanding questions on how the activation of decidual natural killer and T cells, through recognition of key EVT ligands, promotes placentation, tolerance, and immunity.
Fields of Study & Subjects
Reproductive System and Pregnancy
Pregnancy and preeclampsia studies
Immune responses and vaccinations
Publication details
- Journal / source
- Trends in Immunology
- Publisher
- Elsevier BV
- Volume
- 47
- Issue
- 3
- Pages
- 180–183
- Publication date
- 1 March 2026
- Language
- EN