Cooling inflammation through metabolism with 4-octyl itaconate
Abstract
Itaconate is an immunomodulatory metabolite that links metabolism and inflammation. Li et al. uncover a mechanism by which itaconate and 4-octyl itaconate suppress cytokine signaling through the alkylation of tyrosine kinase 2 and Janus kinase 1. This study reveals a direct metabolic control of inflammation and highlights its therapeutic potential in sepsis.
Fields of Study & Subjects
Immune Response and Inflammation
Biochemical Acid Research Studies
Advanced Glycation End Products research
Publication details
- Journal / source
- Trends in Immunology
- Publisher
- Elsevier BV
- Volume
- 47
- Issue
- 5
- Pages
- 348–350
- Publication date
- 1 May 2026
- Language
- EN