Clinical High-Risk for Psychosis in Adolescents: Updated Meta-analysis on Transition Rates and Antipsychotic Prognostic Value

OBJECTIVE: The clinical high-risk for psychosis (CHR-P) paradigm has been widely applied in child and adolescent mental health, yet its prognostic validity in adolescents remains debated. This study aimed to provide an updated meta-analysis of transition rates to psychosis in youth at CHR-P and to assess the influence of baseline antipsychotic (AP) exposure on transition outcomes. METHOD: A systematic review and meta-analysis was conducted following evidence-based guidelines (PROSPERO CRD420251064505). PubMed/MEDLINE and Cochrane Library were searched through August 30, 2025. Eligible studies included participants ≤18 years old or samples with mean age