Changes in Biventricular Cardiac Mechanics After Transcatheter Edge-to-Edge Repair for Severe Tricuspid Regurgitation

BACKGROUND: Transcatheter edge-to-edge repair (TEER) is an established therapy for severe tricuspid regurgitation (TR). Invasive pressure-volume (PV) analysis is the gold standard for characterizing ventricular function and ventricular-vascular interactions. The effects of tricuspid TEER on biventricular PV relationships are unknown. OBJECTIVES: ) ratio; and 3) metabolic demand, represented by PV area (PVA). METHODS: We used a conductance catheter to determine RV and LV PV relationships before and after tricuspid TEER. Pre- and postprocedural changes in cardiac mechanics were compared using the paired-samples t-test or Wilcoxon signed rank test. RESULTS: , PVA, and stroke work-to-PVA remained unchanged. CONCLUSIONS: TR reduction with tricuspid TEER generated immediate RV volume unloading, increased RV afterload, and enhanced RV contractility, maintaining forward stroke volume and increasing LV preload.