Invasive Hemodynamic Validation of the Novel HFpEF-JH Risk Score

Invasive hemodynamics obtained through right heart catheterization (RHC), both at rest and with exercise, are the gold standard in establishing a diagnosis of HFpEF.However, current screening and diagnostic practice remains largely reliant on risk scores.The H 2 FPEF and HFA-PEFF scores are validated diagnostic scores combining age, antihypertensive medications, atrial fibrillation history, body mass index (BMI), and E/e' ratio and systolic pulmonary artery (PA) pressure obtained via echocardiographic measurements to calculate a score, 1 with the HFA-PEFF score also incorporating natriuretic peptide and additional echocardiographic measurements.2 Recently, a new tool for assessing likelihood of HFpEF-the HFpEF-JH score-was introduced.The score incorporates BMI, estimated glomerular filtration rate, left ventricular (LV) mass index, and left atrial/LV ratio.3 This score was shown to have better sensitivity and specificity than H 2 FPEF on initial comparison, particularly in obese-phenotype HFpEF.3 However, the score has yet to be validated against invasive hemodynamic data.4 This study aimed to externally validate the HFpEF-JH score as a screening tool for HFpEF in patients undergoing invasive hemodynamic testing.