Arterial Stiffness Mechanisms and Orthostatic Hypotension in SPRINT

JACC Advances 2026 Open access

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Authors: Ryan J. Pewowaruk, Byron C. Jaeger, Timothy M. Hughes, Bharathi Upadhya, Dalane W. Kitzman, Mark A. Supiano, Adam D. Gepner
DOI: 10.1016/j.jacadv.2026.102734
Cited by: 1
References: 49

Abstract

BACKGROUND: Hypertension is a leading cardiovascular disease risk factor. Intensive blood pressure (BP) control reduces cardiovascular disease events but may be limited by treatment-related serious adverse events (SAEs). OBJECTIVES: The purpose of this study was to determine if baseline carotid to femoral pulse wave velocity (PWV)-including the component of structural stiffening, due to remodeling of the vessel wall, and load-dependent stiffening, due to the BP load on the arterial wall-is independently associated with orthostatic hypotension (OH) and SAEs in the SPRINT (Systolic Blood Pressure Intervention Trial). METHODS: SPRINT compared intensive (

Fields of Study & Subjects

Cardiovascular Syncope and Autonomic Disorders Heart Rate Variability and Autonomic Control Hemodynamic Monitoring and Therapy

Publication details

Journal / source
JACC Advances
Publisher
Elsevier BV
Volume
5
Issue
5
Pages
102734–102734
Publication date
11 April 2026
Language
EN