Opportunistic Genetic Testing for Familial Hypercholesterolemia in Premature Acute Coronary Syndrome

JACC Advances 2026 Open access

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Authors: Nicol Vaizman, Lubomira Cermakova, Matthew Cooper, Adam I. Kramer, Kyle Hui, Linda M. Jackson, Thomas M. Roston, GB John Mancini, Christopher B. Fordyce, Iulia Iatan, Liam R. Brunham
DOI: 10.1016/j.jacadv.2026.103053
Cited by: 1
References: 29

Abstract

BACKGROUND: Familial hypercholesterolemia (FH) is common among patients with premature acute coronary syndrome (ACS) but remains underdiagnosed and undertreated. OBJECTIVES: The ACCURATE (Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia) study evaluated whether opportunistic genetic testing in patients with premature ACS increases FH diagnosis and lipid-lowering therapy use. METHODS: ACCURATE was a nonrandomized, prospective study that recruited 2 sequential cohorts of patients. In phase 1, patients were treated according to usual standard of care, with no genetic testing. In phase 2, patients underwent FH genetic testing with results returned to treating physicians. Eligible patients were

Fields of Study & Subjects

Lipoproteins and Cardiovascular Health Genetic Associations and Epidemiology Diabetes Cardiovascular Risks and Lipoproteins

Publication details

Journal / source
JACC Advances
Publisher
Elsevier BV
Volume
5
Issue
9
Pages
103053–103053
Publication date
7 August 2026
Language
EN