Family History and ASCVD Risk Among Different Age Groups

BACKGROUND: Evidence on the association between family history and atherosclerotic cardiovascular disease (ASCVD) across age groups remains limited. OBJECTIVES: This study aimed to evaluate the relations of family history of ASCVD (FHA) with incident ASCVD and its predictive value across age groups in China-PAR (Prediction for Atherosclerotic Cardiovascular Disease Risk in China) and UK Biobank. METHODS: A total of 117,640 Chinese and 457,781 UK adults were included from 2 population-based cohorts, with family history assured by face-to-face interviews with standardized questionnaires. RESULTS: < 0.001). CONCLUSIONS: In both populations, FHA is a key indicator for identifying high ASCVD risk, especially in younger individuals, with a stronger impact driven by sibling history. These findings highlight the importance of tailoring recommendations for identifying high-risk individuals based on family history, with consideration of different age groups.