Prognosis by Renal Function With or Without Percutaneous Coronary Intervention in Non–ST-Segment Elevation Myocardial Infarction

BACKGROUND: Renal dysfunction increases adverse outcomes in non-ST-segment elevation myocardial infarction (NSTEMI), but evidence comparing percutaneous coronary intervention (PCI) with non-PCI by renal function is limited. OBJECTIVES: The authors aimed to compare 3-year outcomes of PCI versus non-PCI by baseline renal function in NSTEMI. METHODS: ). Primary outcome was 3-year major adverse cardiac and cerebrovascular events (MACCE; defined as all-cause death, recurrent myocardial infarction, or stroke). Multivariable-adjusted Cox regression was performed. Median follow-up was 36.0 months (IQR: 36.0-36.0 months; 40,097 person-years). RESULTS: Worsening renal function was associated with higher MACCE and mortality (all P < 0.001), except between eGFR ≥90 and 60-89. Compared with non-PCI, PCI was associated with lower adjusted risks in the eGFR 60-89, 30-59, and