Physiological Patterns of Coronary Artery Disease and Drug-Coated Balloon Performance

JACC Asia 2026 Open access

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Authors: Simone Fezzi, Filippo Luca Gurgoglione, Mauro Gitto, Hesham Abu Abied, Faisal Sharif, Gabriele Venturi, Luigi Alberto Iossa, Jacek Bezubka, Sylwia Iwańczyk, Wojciech Wańha, Michał Hawranek, Maksymilian Mielczarek
+10 more Piotr Wańczura, Ilya Litovchik, Antoinette Monayer, Ettore Ventura, Stefano Galli, Tuomas T. Rissanen, Flavio Ribichini, Antonio Colombo, Carlos Collet, Bernardo Cortese
DOI: 10.1016/j.jacasi.2026.06.043
Cited by: 1
References: 41

Abstract

BACKGROUND: Diffuse coronary artery disease (CAD) challenges stent-based percutaneous coronary intervention (PCI). Drug-coated balloons (DCBs) offer a stentless strategy, but the physiological response in focal compared with diffuse disease remains unclear. OBJECTIVES: The authors aimed to investigate the impact of physiological patterns on angiographic and physiological outcomes after DCB-PCI. METHODS: In this international cohort, patients underwent DCB-PCI for de novo lesions with angiographic follow-up at 5 months (IQR: 3-7). Quantitative coronary angiography and Murray's law-based quantitative flow ratio (μFR) were analyzed by a core laboratory. Virtual μFR pull backs generated the pull back pressure gradient index (PPGi), classifying disease as focal (PPGi ≥0.78) or diffuse (PPGi

Fields of Study & Subjects

Coronary Interventions and Diagnostics Cardiac Imaging and Diagnostics Acute Myocardial Infarction Research

Publication details

Journal / source
JACC Asia
Publisher
Elsevier BV
Volume
6
Issue
10
Pages
2276-2289
Publication date
1 August 2026
Language
EN