Runx1 in Postn-Expressing Fibroblasts But Not Cardiomyocytes Exacerbates Adverse Cardiac Remodeling Post-Myocardial Infarction

JACC Basic to Translational Science 2026 Open access

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Authors: Kaelin A. Akins, Anooj Arkatkar, Michael A. Flinn, Natalie Sandor, Alexandra L. Purdy, Annabelle Brusacoram, Samantha K. Swift, Sydney L. Buday, Priyanka Choudhury, Miao Cui, Brian Leei Lin, Caitlin C. O’Meara
+1 more Michaela Patterson
DOI: 10.1016/j.jacbts.2025.101455
Cited by: 1
References: 61

Abstract

Runx1 is strongly induced in the heart after acute injury and in chronic disease settings. Its expression negatively correlates with outcomes, and past work demonstrates a protective effect when Runx1 is inhibited through a variety of experimental means. We sought to establish which Runx1-expressing cell type(s) are responsible for the adverse remodeling phenotypes observed upon its induction. Using distinct Cre drivers, we ablated Runx1 from cardiomyocytes and fibroblasts. Following experimental myocardial infarction, we established that loss of Runx1 in fibroblasts, but not cardiomyocytes, is able to protect from adverse remodeling.

Fields of Study & Subjects

Cardiac Fibrosis and Remodeling Congenital heart defects research Cytokine Signaling Pathways and Interactions

Publication details

Journal / source
JACC Basic to Translational Science
Publisher
Elsevier BV
Volume
11
Issue
2
Pages
101455–101455
Publication date
13 January 2026
Language
EN