Cardiopathogenic T Cells Govern Progression and Functional Remodeling in Inflammatory Cardiomyopathy and Chronic Myocarditis

JACC Basic to Translational Science 2026 Open access

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Authors: Anna Joachimbauer, Nadine Cadosch, Cristina Gil-Cruz, Christian Perez-Shibayama, Kira Frischmann, Emily Payne, Isabella Hanka, Micha T. Maeder, H Rickli, Felix Christoph Tanner, Frank Ruschitzka, Burkhard Ludewig
+1 more Dörthe Schmidt
DOI: 10.1016/j.jacbts.2025.101458
Cited by: 1
References: 53

Abstract

Echocardiographic imaging mirrors the immunopathological processes underlying the progression from acute myocarditis to inflammatory cardiomyopathy. T cell-mediated myocardial inflammation and edematous swelling in subepicardial regions at disease onset is followed by smoldering low-level myocardial inflammation or increasing cardiomyocyte loss and fibrotic remodeling. The resulting decline of cardiac function in the progressive disease is reflected and best predicted by impaired echocardiographic strain.

Fields of Study & Subjects

Viral Infections and Immunology Research Cardiac Fibrosis and Remodeling Pericarditis and Cardiac Tamponade

Publication details

Journal / source
JACC Basic to Translational Science
Publisher
Elsevier BV
Volume
11
Issue
2
Pages
101458–101458
Publication date
12 January 2026
Language
EN