Methylated PIH1D1 as a Circulating Biomarker for Anthracycline-Related Cardiac Remodeling
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odern oncology therapies have made great advances in reducing mortality, but a side effect of this is the potential for survivor-morbidity, especially with respect to cardiac status.For example, the drug class known as anthracyclines are well known as potentially cardiotoxic and can induce pathologic cardiac remodeling leading to heart failure and other disorders of cardiac function.1 Although guideline markers such as cardiac troponin (cTn) and B-type natriuretic peptide (BNP) can assist in the recognition of cardiac damage, they are only useful a posteriori in its development and are also susceptible to circulating concentration changes induced by noncardiac conditions. 2 Thus,
Fields of Study & Subjects
Chemotherapy-induced cardiotoxicity and mitigation
Cardiac Fibrosis and Remodeling
Cardiomyopathy and Myosin Studies
Publication details
- Journal / source
- JACC Basic to Translational Science
- Volume
- 11
- Issue
- 4
- Pages
- 101525–101525
- Publication date
- 16 March 2026
- Language
- EN