Synergistic Effects of SGLT2 Inhibitors and GLP-1R Agonists on Inflammation-Associated Oxidative Stress in Atrial Fibrillation

JACC Basic to Translational Science 2026 Open access

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Authors: Walaa Fakih, Ali Mroueh, Shinnosuke Kikuchi, Halim Marzak, Said Amissi, Dal-Seong Gong, Sophie Kerth, M K Kindo, Arnaud Mommerot, Michael Pieper, Patrick Ohlmann, Olivier Morel
+2 more Valérie Schini-Kerth, Laurence Jesel
DOI: 10.1016/j.jacbts.2026.101587
Cited by: 3
References: 28

Abstract

Atrial fibrillation (AF) is linked to atrial inflammation and adverse remodeling. The authors analyzed 80 right atrial appendages from cardiac surgery patients, including 18 with AF history, to examine the relationship between inflammation and sodium-glucose cotransporter 2 (SGLT2) and glucagon-like peptide 1 receptor (GLP-1R) expression and function. Inflamed right atrial appendages showed increased oxidative stress, fibrosis, and SGLT2 and GLP-1R expression, which were more pronounced in patients with AF. SGLT2 inhibitors and GLP-1R agonists reduced reactive oxygen species levels, with combination therapy being most effective. These findings suggest combined SGLT2 inhibitor and GLP-1R agonist treatment could be a potential approach to prevent AF-related atrial remodeling by reducing oxidative stress.

Fields of Study & Subjects

Diabetes Treatment and Management Atrial Fibrillation Management and Outcomes Advanced Glycation End Products research

Publication details

Journal / source
JACC Basic to Translational Science
Publisher
Elsevier BV
Volume
11
Issue
7
Pages
101587–101587
Publication date
6 June 2026
Language
EN