Impaired Cardiac Myosin Super-Relaxation as an Energy-Dissipating Process in Human Heart Failure with Reduced Ejection Fraction

JACC Basic to Translational Science 2026 Open access

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Authors: Weikang Ma, Chahida Chaami, Elise Gerlach Melhedegaard, Christopher T. A. Lewis, Chengxin Zhang, Meihua Guo, Hailey Flannagan, Maicon Landim-Vieira, W. Glen Pyle, Kenneth S. Campbell, Julien Ochala
DOI: 10.1016/j.jacbts.2026.101651
Cited by: 1
References: 31

Abstract

Systolic heart failure is increasingly recognized as a disease of impaired cardiac energy metabolism. Here, the authors show that cardiac myosin super-relaxation (an energy-conserving myosin state) is destabilized in failing human myocardium. Importantly, this loss of energy conservation is associated with elevated post-translational modifications (phosphorylation and acetylation) rather than gross structural changes in thick filament organization. Hence, targeting post-translational modifications signaling pathways opens new therapeutic opportunities.

Fields of Study & Subjects

Cardiomyopathy and Myosin Studies Cardiovascular Function and Risk Factors Cardiac electrophysiology and arrhythmias

Publication details

Journal / source
JACC Basic to Translational Science
Publisher
Elsevier BV
Volume
11
Issue
9
Pages
101651–101651
Publication date
18 August 2026
Language
EN