Managing Pregnancy in the Presence of Rheumatic Heart Disease and Antiphospholipid Syndrome

JACC Case Reports 2026 Open access

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Authors: Syed Bassim Zahid, Mannal Ahmed, Reema Qayoom, Hannah S. Asghar
DOI: 10.1016/j.jaccas.2025.106399
Cited by: 0
References: 8

Abstract

BACKGROUND: Rheumatic heart disease remains a major cause of maternal morbidity and mortality in low- and middle-income countries. The coexistence of severe mitral stenosis (MS) and antiphospholipid syndrome presents an exceptionally high-risk clinical scenario requiring multidisciplinary management. CASE SUMMARY: , and she delivered a healthy baby at term without complications. DISCUSSION: Pregnancy in women with rheumatic MS and antiphospholipid syndrome demands coordinated care to balance hemodynamic and thrombotic risks while ensuring fetal safety. TAKE-HOME MESSAGE: Timely cardiac intervention, multidisciplinary collaboration, and individualized care enable favorable maternal and fetal outcomes in complex high-risk pregnancies.

Fields of Study & Subjects

Cardiovascular Issues in Pregnancy Systemic Lupus Erythematosus Research Cardiac Valve Diseases and Treatments

Publication details

Journal / source
JACC Case Reports
Volume
31
Issue
13
Pages
106399–106399
Publication date
14 January 2026
Language
EN