Atypical Presentations of Coronary Microvascular Dysfunction in Patients After COVID

JACC Case Reports 2026 Open access

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Authors: Nisarg Ray, Ahan Kayastha, Krunal Shukla, Michael R. Massoomi, Ellen C. Keeley, Natalie Bracewell
DOI: 10.1016/j.jaccas.2026.107508
Cited by: 1
References: 10

Abstract

Coronary microvascular dysfunction is a recognized cause of angina without obstructive coronary disease, yet routine tests are often nondiagnostic. In this case series, we describe 3 previously active adults with persistent chest pain after SARS-CoV-2 infection who fulfilled the World Health Organization criteria for postacute sequelae. All 3 patients underwent invasive coronary angiography with coronary reactivity testing with coronary flow reserve (CFR). In all patients, the epicardial coronary arteries were angiographically normal, however CFR was significantly impaired (

Fields of Study & Subjects

COVID-19 Clinical Research Studies Kawasaki Disease and Coronary Complications Long-Term Effects of COVID-19

Publication details

Journal / source
JACC Case Reports
Publisher
Elsevier BV
Volume
31
Issue
18
Pages
107508–107508
Publication date
4 April 2026
Language
EN