EDP-978, a Potent KIT Inhibitor, Demonstrated Dose-dependent Target-Engagement and a Favorable Pharmacokinetic Profile with Once-Daily Dosing Potential in Humans

Lijuan Jiang; Yang Li; Lisha Xu; Jonathan Kibel; Daniel Léonard; Tianzhu Zang; Shucha Zhang; Meng Huang; Khanh Hoang; Siu‐Lung Chan; Joshua J. Klaene; Kellye K. Daniels; Yat Sun Or

doi:10.1016/j.jaci.2025.12.044

EDP-978, a Potent KIT Inhibitor, Demonstrated Dose-dependent Target-Engagement and a Favorable Pharmacokinetic Profile with Once-Daily Dosing Potential in Humans

Journal of Allergy and Clinical Immunology 2026 Open access

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Authors: Lijuan Jiang, Yang Li, Lisha Xu, Jonathan Kibel, Daniel Léonard, Tianzhu Zang, Shucha Zhang, Meng Huang, Khanh Hoang, Siu‐Lung Chan, Joshua J. Klaene, Kellye K. Daniels

+1 more

Yat Sun Or

DOI: 10.1016/j.jaci.2025.12.044

Cited by: 0

Fields of Study & Subjects

Mast cells and histamine Urticaria and Related Conditions Asthma and respiratory diseases

Publication details

Journal / source: Journal of Allergy and Clinical Immunology
Volume: 157
Issue: 2
Pages: AB13–AB13
Publication date: 1 February 2026
Language: EN