Platelet–macrophage cooperation drives IL-33–dependent type 2 lung immunopathology in a sex-biased manner

Journal of Allergy and Clinical Immunology 2026 Open access

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Authors: Hiroaki Hayashi, Jun Nagai, Juying Lai, Kendall Zaleski, Chunli Feng, Madeline Hastings, Airi Nishida, Yumi Tani, Junrui Lin, Marie Sasaki, Kinan Alhallak, Sofia A. Marshall
+3 more Tao Liu, Barbara Balestrieri, Joshua A. Boyce
DOI: 10.1016/j.jaci.2025.12.1012
Cited by: 3
References: 91

Abstract

BACKGROUND: Platelets amplify lung type 2 inflammation (T2I), but the underlying mechanisms remain incompletely understood. OBJECTIVE: ). METHODS: and IL-33 in naïve mice complemented the genetic models. Sex- and age-matched mice were randomly assigned, and histopathologic evaluations were performed under blinded conditions. RESULTS: Macs and expanded AT2 cells. CONCLUSION: sustains IL-33-driven expansion of AT2 cells and group 2 innate lymphoid cells, driving sex-biased amplification of T2I. This platelet-Mac axis may contribute to sex differences in type 2 inflammatory airway diseases such as asthma.

Fields of Study & Subjects

IL-33 ST2 and ILC Pathways Asthma and respiratory diseases Eosinophilic Esophagitis

Publication details

Journal / source
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Volume
157
Issue
6
Pages
1365–1379
Publication date
22 January 2026
Language
EN